Macrofungi have been utilized as a food source for thousands of years and contribute significantly to human health and nutrition. The increasing recognition of macrofungi as a valuable food source has resulted in an exponential increase in global production, trade and consumption of macrofungi. Thus, in this article, we present up-to-date information on the types and use of macrofungi as food, current trade and production volumes and how macrofungi contribute to human health and nutrition. Furthermore, we include a discussion on the latest information regarding which species of macrofungi are safe to eat.